You just can’t stand it anymore. Your job is all wrong. Getting up for work each morning is an exercise in misery. Or maybe your work is having a negative effect on your life. Should you quit?

It’s a topic several LinkedIn Influencers weighed in this week. Here’s what two of them had to say about the right time to quit — be it because you hate a job or your life takes an unexpected turn.

Murugan Pandian, project efficiency expert at St Joseph’s Hospital Health Center

Do you ever ask yourself why you are still going to the job that you hate every day? You probably have reluctantly accepted it as being part of your daily life. You might also be thankful that you at least have a job and it pays the bills,” wrote Pandian in his post Why you need to quit the job that you hate.

But, wrote Pandian, don’t give into those thoughts. “If you are uninspired by your job, then my advice to you is to quit,” he wrote.

Why not stick it out? Because, he wrote, if you spend so many hours at something you loathe, "it is going to impede your ability to do your best work.”

As much as you try to hide it, others likely know you are disengaged. That hurts your relationships with colleagues. “If you do not have a mentor or people to advocate for you at your current job, then it is going to be very hard to grow professionally,” Pandian wrote.

Of course, it’s best to have another job or opportunity lined up before you tender your resignation, right? Not always.

“People will always say don't quit your job before you get the next one lined up. It is true that being employed when looking for the next gig does help tremendously,” he wrote. “However, if you are that miserable then sometimes it helps to quit, reassess your priorities in life and then come up with a more creative job hunting strategy.”

But, don’t worry if you’ve been at a position only a short time when you leave, he wrote. “Do not worry about what others might think, because you are doing what is best for your career. At the end of the day, no one is going to care about how long you were at a particular job,” Pandian wrote.

Nicola Roark marketing consultant at Exhilaration Marketing

The best decision I ever made was when I was 32. I decided to abandon a job I enjoyed at a point when I was finally getting noticed, get on a plane when seven and a half months pregnant and have my baby in England,” wrote Roark in her post When to Turn Your Back on Your Career. “I did this so that I could be with my parents while my mum was dying.”

Roark had wrestled with the decision for months as she pursued her career in Colorado in the United States. Then her mother’s health took a turn for the worst.

“I didn’t feel panic about the decision because I knew that was where I needed and, more importantly, wanted to be,” she wrote.

Of course, quitting one’s job and living at home temporarily with a parent — financial suicide to some — isn’t something that can usually be done on a whim. But, wrote Roark when it matters, it’s the right choice. “If you find yourself consumed by your career identity… I will tell you that it means nothing,” she wrote.

“It would have been easier financially and professionally to stay with my job and go only when I received the inevitable call that we were in the final stretch,” she wrote. “Was it the best decision for my career? I’ll never know and honestly, I don’t care… (It) continues to be the best decision I ever made.”

To comment on this story or anything else you have seen on BBC Capital, head over to our Facebook page or message us on Twitter.