Lung infection identified using 'breath-print'

Patient having his breath sampled and analysed A patient having his breath sampled and analysed

Related Stories

Identifying the "smell" of different types of lung bacteria could lead to a simple breath test to diagnose infections, a study on mice, in the Journal of Breath Research, suggests.

Breath analysis could reduce lung infection diagnosis times from weeks to minutes, the Vermont researchers said.

Scientists have already researched breath tests to diagnose asthma and cancer.

An expert said breath analysis was "an important and emerging field".

Diagnosing bacterial infections traditionally means collecting a sample that is used to grow bacteria in the lab. This bacteria is then tested to classify it and see how it responds to antibiotics, which can take time.

Doctors see breath analysis, in contrast, as a fast and non-invasive method of diagnosing diseases.

Start Quote

Breath analysis is an emerging field and is likely to take off across the board.”

End Quote Prof Richard Hubbard Nottingham City Hospital

For the study, researchers from the University of Vermont analysed volatile organic compounds (VOCs) given off in exhaled breath by different bacteria as well as different strains of the same bacterium.

They infected mice with two bacteria that are both common in lung infections - Pseudomonas aeruginosa and Staphylococcus aureus - and sampled their breath after 24 hours.

'Useful tool'

The compounds in their breath were analysed using a technique called secondary electrospray ionisation mass spectrometry (SESI-MS), which is capable of detecting extremely small elements of the chemicals present in their breath.

The researchers said they found a "statistically significant" difference between the breath profiles of the mice infected with the bacteria and the mice that were uninfected.

They also said they were able to differentiate between two species of bacteria and two different strains of the same P. aeruginosa bacterium.

But Jane Hill, co-author of the study, from the University of Vermont College of Medicine, said there were still some challenges to overcome with "breath-prints".

"We are now collaborating with colleagues to sample patients in order to demonstrate the strengths, as well as limitations, of breath analysis more comprehensively," she said.

Richard Hubbard, professor of respiratory epidemiology at Nottingham City Hospital and a spokesman for the British Lung Foundation, said breath analysis was already being used to diagnose children with asthma.

"Breath analysis is an emerging field and is likely to take off across the board. It could be a very useful tool for children with cystic fibrosis, for example, as a guide on how to treat them," he said.

More on This Story

Related Stories

The BBC is not responsible for the content of external Internet sites

More Health stories

RSS

Features & Analysis

BBC Future

(Thinkstock)

Why all babies love peekaboo

Lessons learned behind the laughter Read more...

Programmes

  • Joe Ierardi playing a pianoClick Watch

    Meet the man trying to create the perfect digital piano - but is it as good as the real thing?

BBC © 2014 The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.