Light in womb 'gives healthy eyes' - in mice

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Light passing through the body and into the womb has an important role in the developing eye, US researchers have discovered.

A study, published in the journal Nature, showed that mice spending pregnancy in complete darkness had babies with altered eye development.

It indicated tiny quantities of light were needed to control blood vessel growth in the eye.

The researchers hope the findings will aid understanding of eye disorders.

Light or dark?

If you could journey inside a mouse or a person, there would not be enough light to see. However, tiny quantities of light do pass through the body.

This effect has already been used to film an infection spreading through the body.

Start Quote

It's not something subtle here, it's a major effect on the way the retina develops”

End Quote Prof Richard Lang Cincinnati Children's Hospital

Now scientists - at the University of California, San Francisco, and Cincinnati Children's Hospital Medical Center - believe that body-penetrating light can alter the development of the eye, at least in mice.

Normally, a network of blood vessels known as the hyaloid vasculature is formed to help nourish the retina as it is constructed.

However, the blood vessels would disrupt sight if they remained, so they are later removed - like scaffolding from a finished building.

The researchers said this did not happen when the pregnancy was spent in total darkness.

The critical period was around 16 days - which is very late in mouse gestation, but corresponds to the first trimester in people.

"It's not something subtle here, it's a major effect on the way the retina develops that requires light going through the body," said Prof Richard Lang, from Cincinnati Children's Hospital.

He said it was a "huge surprise" that this was happening.

Premature babies

The researchers hope their findings may aid understanding of human diseases of the eye, as many are down to blood vessels.

Some babies born prematurely develop "retinopathy of prematurity", when the blood vessels in the eye grow abnormally resulting in damage to the retina and a loss of vision.

Prof Lang said: "In retinopathy of prematurity there is overgrowth of blood vessels and that's what you see in these mice."

The researchers showed that light was activating in the mice a protein, melanopsin, which also has a role in regulating the body clock, and is present in people. However, whether the same processes take place in people or other animals is unknown.

Prof Robin Ali, from University College London, said it was a "fascinating study".

He said more research was still needed, but the findings may lead to considerations of light levels during pregnancy and efforts to grow retinas in the laboratory.

He said: "It gives us a whole new aspect to consider in in the development of the retina.

"It illustrates how much we've yet to understand about the eye."

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