Genetic cause of 'spongy hands' discovered

Skin condition With water (left) and without

Related Stories

Scientists have mapped the gene behind a rare skin condition where hands turn white and spongy in water.

Studies of British and Swedish families with the condition revealed a genetic change in a key chemical that controls water loss from the body.

About one in 40,000 people have the disease, which causes thickened skin on the palms and soles.

Researchers in London say the discovery will aid understanding of how the skin moisturises itself.

The genetic study gives an insight into how the skin barrier functions, said David Kelsell, professor of human molecular genetics at Queen Mary, University of London, who led the team.

He said the research, published in The American Journal of Human Genetics, could also help investigations into other skin conditions.

"This may help us understand more about how the skin moisturises itself naturally," Prof Kelsell told BBC News.

"Everyone knows that when you sit in the bath for an hour your skin goes white and wrinkly. This is what happens in people [with the skin condition]- but it just happens a bit quicker."

The condition is called diffuse non-epidermolytic palmoplantar keratoderma.

The underlying cause is a fault in a substance called aquaporin 5, which plays a role in the generation of saliva, tears and other secretions.

The research shows it is also present in the skin, with higher amounts in the hands and feet.

The gene change appears to make the skin more porous, allowing water to permeate the skin more rapidly.

More on This Story

Related Stories

More Health stories


Features & Analysis

BBC Future

(Getty Images)

The man who studies evil

He spots the ‘everyday sadists’ among us


  • Temperature remoteThe Travel Show Watch

    The remote to control the temperature of your shoes plus other travel gadgets reviewed

Copyright © 2015 BBC. The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.