Brain blow leaves life-long dangers
Injuries to the head can leave victims susceptible to early death even years later through impaired judgement, a major analysis of survivors shows.
Those with a history of psychiatric disorders before the injury are most at risk of dying prematurely.
The study, in JAMA Psychiatry, of 40 years of data on more than two million people, showed that overall a brain injury trebled the risk.
Suicide and fatal injuries were among the commonest causes of early death.
More than one million people in Europe are taken to hospital with a traumatic brain injury each year.
The study, by researchers at the University of Oxford and the Karolinska Institute in Stockholm, looked at Swedish medical records between 1969 and 2009.Treatable illnesses
They followed patients who survived the initial six-month danger period after injury.
The data showed that without injury 0.2% of people were dying prematurely - before the age of 56.
However, the premature-death rate was three-fold higher in patients who had previously suffered traumatic brain injury.
In those who also had a psychiatric disorder the rate soared to 4%.
Dr Seena Fazel, one of the researchers in Oxford, said: "There are these subgroups with really high rates, and these are potentially treatable illnesses, so this is something we can do something about."Judgement affected
Common causes of premature death among those who had suffered previous brain injury included suicide, being a victim of assault or suffering fatal injuries, for example in a car crash.
It is thought that the injury causes permanent damage to neural networks in the brain and can alter people's judgement and ability to deal with new situations.
Prof Huw Williams, the co-director of the centre for clinical neuropsychology research at the University of Exeter, said: "The mortality rates are like a reverse-iceberg - they're the most awful outcome, but the rates of depression and anxiety are huge in the brain injury population.
"People with head injury need monitoring all the time in case they become suicidal."
Dr Richard Greenwood, a consultant neurologist at Homerton Hospital in London, said post-mortem examinations showed 2% of people had evidence of brain injury.
His wife will not let the children play rugby because of the risk to the brain.