Luton Town v Millwall FC: Police plan 'large, visible presence'
About 300 officers will work at Saturday's FA Cup fifth-round tie between Luton Town and Millwall FC at Kenilworth Road, police said.
Bedfordshire Police promised "a large and very visible presence", including on trains approaching the town.
It said policing for the game, which will kick off at 12:45 GMT, was a "slightly larger operation" than the usual arrangements for matches.
In 1985 violence marred an FA Cup match between the two sides.
The operation for this game will include officers from Hertfordshire and Cambridgeshire, along with British Transport Police and Thames Valley Police, who are assisting with a dog section and mounted officers.
Det Ch Supt Mike Colbourne said: "This is a slightly larger operation than a similar game that we would have during the season.
"Where there are extra elements around the game, sheer weight of numbers coming in, the importance of it, and the need to move fans around, we put on bespoke policing arrangements.
"A few fans may be coming with the intention to cause trouble but we have learnt clearly over three decades how to deliver really good effective operations to combat hooliganism."