M50 embankment work under way near Twyning junction
Work has started to stabilise an embankment on the M50, on the Gloucestershire/Worcestershire border.
The Highways Agency said the work was needed to stop subsidence damaging the road surface and the crash barriers.
Drivers travelling west will be unable to use the M50 slip roads at junction one between 22:00 GMT on Friday and 06:00 on Monday.
A full closure westbound is due between the two junctions from 20:00 on Sunday until 06:00 Monday.
A Highways Agency spokeswoman said: "The work is needed to repair subsidence of the embankment which is undermining the safety of the carriageway and crash barriers.
"While carrying out that work we will take advantage of the traffic management to carry out other work such as resurfacing and drainage, which will remove the need to come back a second time."
The work was planned to take place in November and would have seen junction one westbound closed for five months.
But following feedback from residents, and the intervention of the Tewkesbury MP Laurence Robertson, the work was put on hold and the scope of the project was adjusted.