Dundee researchers find chemotherapy efficacy gene

Ovarian Cancer Researchers at Dundee University found the gene FGF1 was highly active in aggressive, advance ovarian cancers.

Related Stories

Dundee University researchers believe they have found a way to predict the effectiveness of chemotherapy drugs in fighting ovarian cancer.

Scientists have discovered a gene called FGF1 was highly active in aggressive, advanced ovarian cancers.

They observed it was present at higher levels in cancer cells that were resistant to a common treatment for the disease.

The team hope the findings help to develop new cancer treatments.

Researchers measured amounts of a variety of genes in 187 ovarian cancer patients and found each cancer had a unique range of active genes.

Drug resistant

However, FGF1 appeared to playing the greatest role in determining how cancers behave.

The team, based at the University's School of Medicine, found the gene called FGF1 was found at higher levels in cancer cells that are resistant to platinum chemotherapy treatments, such as carboplatin and cisplatin.

As a result, women with high levels of FGF1 are less likely to respond to these drugs and have a poorer prognosis.

The scientist believe measuring how active the gene is could predict which women with ovarian cancer will benefit from the drugs.

Paving the way

Dr Gillian Smith, who was involved in the study, said: "We're excited by these results because they identify potential ways that ovarian cancer builds resistance to common chemotherapy drugs over time.

"Our study paves the way for the development of new tests to determine if chemotherapy will work and suggests that drugs targeting FGF1 could be effective new treatments for a group of women with a type of ovarian cancer that is difficult to treat successfully."

The also discovered FGF1 activity increases after ovarian cancer cells become drug resistant.

The scientists learned that by blocking FGF1 in ovarian cancer cells resistant to platinum drugs, they were able to make them sensitive to chemotherapy again.

The study, funded by Cancer Research UK and the Scottish Funding Council, has been published online in the British Journal of Cancer.

More on This Story

Related Stories

The BBC is not responsible for the content of external Internet sites

BBC Tayside & Central

Weather

Dundee

Min. Night 4 °C

Features & Analysis

  • TricycleTreasure trove

    The lost property shop stuffed with diamonds, bikes... and a leg


  • Boris Nemtsov'I loved Nemtsov'

    A murder in an atmosphere of hatred and intolerance


  • Image of George from Tube CrushTube crush

    How London's male commuters set Chinese hearts racing


  • INDHUJA'Dorky tomboy'

    The Indian who attracted proposals through honesty


Elsewhere on the BBC

  • Audi R8Best in show

    BBC Autos takes a look at 10 of the most eye-catching new cars at the 2015 Geneva motor show

Programmes

  • Kinetic sculpture violinClick Watch

    The "kinetic sculpture" that can replicate digital files and play them on a violin

Try our new site and tell us what you think. Learn more
Take me there

Copyright © 2015 BBC. The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.