Missing Newport biochemist David Hampton's family appeal for help
Police and friends have appealed for help in tracing a man who went missing after going out to a shop.
Dr David Hampton, 64, from Pill in Newport, disappeared on Thursday at around 23:00 BST.
The biochemist's family believe he had been suffering from a virus in the days before going missing, which had left him "confused" and "dazed".
Gwent Police have appealed for any witnesses to contact them on 101.
Dr Hampton does not suffer from depression and his behaviour has been called completely out of character.
Close family friend Alison Harrison, speaking on behalf of the family, said Dr Hampton, who works at the Royal Gwent Hospital in Newport, had been off work because of the virus.
"It was very unusual for him to take to his bed, he's not the sort of man to do that," she said.
Dr Hampton refused to see his GP and visited his son in Carmarthen on Thursday, where his partner became increasingly concerned about his behaviour.
Ms Harrison said: "He was acting very oddly. It was almost like he wasn't quite with it."
His partner Sara Webb raised the alarm after he failed to return from a visit to a shop on Thursday night.
He is known to have gone to the Red Lion on Stow Hill, as he was spotted on CCTV.
He then walked along the river towards a travellers' site at Spytty, where a tracker is still locating his mobile phone.
Dr Hampton was also spotted on CCTV near the Motorpoint car dealership and it is also thought he spoke to a security guard at the city's recycling plant in Spytty.
Gwent Police, who have been searching in the Spytty area, have issued an appeal for help in tracing Dr Hampton.
He is described as 5ft 8ins and stocky. He has short, grey and shaved hair and sometimes wears glasses. He was wearing a navy jumper, light blue shirt, grey jeans and black shoes.