Sheffield United centre-back Harry Maguire scored twice against Crewe to help Sheffield United boss Nigel Clough secure victory in his first game.
Maguire headed the Blades into the lead from Stephen McGinn's free-kick and netted his second from the same player's delivery from a corner.
The Blades sealed the win when Ryan Flynn cut inside to thump home.
Substitute Chuks Aneke hit the bar for the visitors before Max Clayton pulled one back late on.
Sheffield United's third win of the season saw them move out of the League One relegation zone, at the expense of their opponents.
The Railwaymen, who fell to a 3-0 home defeat by Stevenage on Tuesday, have now lost five of their last seven in all competitions.
VIEW FROM THE DRESSING ROOM
Sheffield United manager Nigel Clough tells BBC Radio Sheffield:
"Delighted with the three points and the response from the players.
"Chris Morgan takes a lot of credit for what he's done this week. Seven points from nine from the position we're in is a great return.
"We had great energy for the first hour, then we ran out of steam a little bit late on.
"But we got the three goals ahead and Crewe are the sort of side that are just going to keep passing and playing."
Sheffield United 25 Long 29 McMahon 06 Hill 14 McGinn 05 Maguire 15 Collins 07 Flynn 08 Doyle 10 Taylor (Coady - 82' ) 18 King (Miller - 69' ) 22 Lappin (Cuvelier - 90' ) Substitutes 01 Howard 02 Westlake 11 Baxter 12 Miller 16 Cuvelier 17 Coady 23 Murphy Crewe Alexandra 01 Phillips 03 Mellor 02 Tootle 20 Turton (Aneke - 57' ) 12 Ray 06 Dugdale 11 Moore 08 Osman 19 Oliver 14 Inman Booked (Clayton - 74' ) 42 Grant Substitutes 05 Ellis 07 Clayton 16 Guthrie 18 Nolan 22 Garratt 24 Molyneux 26 Aneke