Kwesi Appiah scored twice as leaders Cambridge maintained their 100% record at home with victory over Macclesfield.
The Crystal Palace loan striker opened the scoring when he picked the ball up inside his own half and sprinted past three players before lashing in.
His second was a lobbed effort over keeper Rhys Taylor 10 minutes later.
An in-swinging corner from Macc midfielder Jack Mackreth forced Chris Maxwell into a good save, before Josh Gillies fired in a third for the U's.
VIEW FROM THE DRESSING ROOM
Cambridge United manager Richard Money told BBC Radio Cambridgeshire:
"It would be easy for me to say I thought that was our best of the season - but I think it was the most important of the season.
"A lot of people said to me before kick-off that there might be a bit of a backlash (from Sunday's FA Cup loss to Sheffield United).
"But the reality is they just don't know this group. It was an absolutely terrific, tremendous performance.
"Macclesfield aren't bad, but our defensive organisation was brilliant and we always look dangerous."
Cambridge United 01 Maxwell 06 Miller 02 Roberts 04 Coulson 03 Taylor 08 Champion 29 Gillies 18 Berry 21 Appiah (Arnold - 87' ) 09 Cunnington 17 Hughes Substitutes 16 Austin 22 Spillane 23 Ledsham 32 Brown 24 Arnold Macclesfield Town 01 Taylor 03 Andrew 04 Martin (Connor - 23' Booked ) 26 Halls 12 Williams 06 Turnbull 23 Whitaker 07 Mackreth 24 Rowe (Kay - 53' ) 19 Boden (Holroyd - 79' ) 08 Jennings Booked Substitutes 02 Connor 09 Holroyd 15 Lewis 11 Winn 25 Kay
Ref: Simon Bennett