Jockeys Paul Doe and Greg Fairley have been banned from racing for 12 years for "not riding a horse to its merits" after an investigation into corruption.
Two other jockeys are among 11 people barred from the sport following a British Horseracing Authority probe.
Kirsty Milczarek has been banned for two years, while Jimmy Quinn has received a six-month punishment.
Owners Maurice "Fred" Sines and James Crickmore have been banned for 14 years for betting on their own horse to lose.
Fairley and Doe had both quit racing earlier this year.
BBC sports news correspondent
“This investigation is the largest of its type ever undertaken in British racing. It stemmed from suspicious activity on betting exchanges, where money can be gambled on horses losing races, as well as winning”
Quinn and Milczarek were both found guilty of corruption, but the latter was also found to have breached a rule forbidding jockeys passing on information in return for reward.
Quinn, who has ridden four winners for champion trainer Richard Hannon this year, does not intend to appeal while Milczarek does.
Five others - Nick Gold, Peter Gold, Shaun Harris, David Kendrick and Liam Vasey - were also found guilty of "corrupt or fraudulent practice".
Vasey, Kendrick and Harris were banned for five, four and three years respectively while a decision on Nick and Peter Gold's penalties will be made after further written submissions.
Paul Fitzsimons, now a trainer, and Darren May were cleared of all charges.
All those found guilty have seven days to appeal against their bans but are excluded from the sport during that period.
The verdicts were delivered on Wednesday as the BHA published the findings of its long-running investigation into race-fixing around horses being backed on betting exchanges to lose races between 17 January and 15 August 2009.
- Paul Doe - jockey - 12 years
- Greg Fairley - jockey - 12 years
- Jimmy Quinn - jockey - six months
- Kirsty Milczarek - jockey - two years
- Maurice "Fred" Sines - owner - 14 years
- James Crickmore - owner - 14 years
- Shaun Harris - associate - three years
- David Kendrick - associate - four years
- Liam Vasey - associate - five years
- Nick Gold - associate - TBA
- Peter Gold - associate - TBA
"While it is the names of the jockeys that the racing public will recognise, people should be under no illusions that it is the lesser-known names who were the instigators of these serious breaches of the rules," said BHA director Paul Scotney.
"The investigation uncovered a network through which Sines and Crickmore engaged in betting activity, in particular with two riders, Paul Doe and Greg Fairley, that impacted on seven of the 10 races in question.
"In the BHA's history, the scale and complexity of this case is unprecedented."
Quinn's solicitor Rory Mac Neice
told the Racing Post:
"The BHA found that Jimmy had ridden both horses on their merits and went as far to say that he did not stop the horses and that if he had been asked to stop the horses he would not have done so anyway.
"Jimmy is pleased that this has been made clear to the outside world.
"In giving him a six-month ban they have given him the minimum amount open to them and that reflects the panel's view of him."
Milczarek, who was in action at Lingfield and Kempton on Wednesday afternoon, faced charges relating to her ride aboard Obe Gold at Lingfield on 15 August 2009.
Trained at the time by Debbie Mountain, Milczarek, the girlfriend of six-time champion jockey Kieren Fallon, finished fifth on the even-money favourite in a six-furlong race.
She told At The Races: "I've just spoken to my solicitor a couple of times. We are going for an appeal. It's my livelihood.
"I was found guilty on one particular thing but not a ride, which I'm pleased about."
Nick and Peter Gold also intend to contest the guilty verdicts in their cases.
"We wish to make clear on behalf of our clients that the BHA disciplinary panel expressly found that our clients were not involved in any conspiracy whereby bets were placed on races knowing that jockeys had agreed to lose the races in question," read a statement from their solicitors.
"The BHA panel nevertheless went on to find our clients in breach of the rules of racing 'in the lesser sense' that some inside information from jockeys had been used.
"Our clients will vigorously contest the findings against them."