Match ends, Tottenham Hotspur 2, KAA Gent 2.
Tottenham 2-2 Gent (agg 2-3)
Ten-man Tottenham Hotspur were knocked out of the Europa League as Gent held them to a draw at a sell-out Wembley.
Spurs, who trailed 1-0 after the first leg of the last-32 tie, made a great start as Christian Eriksen slipped an angled shot under Gent keeper Lovre Kalinic.
The visitors equalised through Harry Kane's own goal, leaving Spurs needing to score twice more in front of a Europa League record attendance of 80,465.
Their task became harder when midfielder Dele Alli was sent off shortly before half-time for a dangerous high tackle.
Victor Wanyama's curler into the top-left corner revived Spurs' hopes, only for substitute Jeremy Perbet to prod Gent into the last 16 with fewer than 10 minutes left.
Spurs' elimination means they have only reached the Europa League quarter-finals once in the past six seasons.
Manchester United, who beat French side Saint-Etienne 4-0 on aggregate, will be the only British side in the last-16 draw on Friday (12:00 GMT).
Spurs pay price for Alli red card
Despite them needing to score at least twice as the match approached half-time, few would have written off Spurs.
But they were then reduced to 10 men after Alli's poor tackle.
The 20-year-old England midfielder has previously shown glimpses of a fiery streak, alongside his technical brilliance, but this was the first red card of his career.
Alli felt referee Manuel de Sousa should have given him a free-kick close to the halfway line and briefly remonstrated with the Portuguese official before turning and launching into Genk midfielder Brecht Dejaegere with a studs-up challenge.
Alli caught Dejaegere just under his right knee - and luckily the Belgian appeared to escape serious injury.
Tottenham did not escape without damage, though.
Spurs' European struggles continue
Tottenham, particularly since Mauricio Pochettino became manager, have often drawn praise for their fearless and confident approach, and they have become regular title challengers.
But it is a different story in Europe.
In truth, they should still have progressed despite Alli's dismissal, only poor finishing costing them in a dominant performance against a team containing a man extra.
The blame largely lies in a lifeless performance in Belgium.
Gent's first-leg victory was only their third win in 13 matches, with their recent form dropping them to eighth place in a Belgian top flight ranked as only the ninth-best European league.
Indeed Belgian leaders Club Brugge, the reigning champions, lost all six matches in their Champions League group, including a 3-0 home defeat and 2-1 loss against Leicester City.
While Tottenham's deficiencies were clear, Gent deserve credit. They were organised, disciplined and clinical when their rare chances arrived.
Perbet, who scored the winner last week, put the tie beyond Spurs with the away team's first shot on target at Wembley, sparking exuberant scenes among the 10,000 visiting fans.
Tottenham manager Mauricio Pochettino:
"I am very disappointed. Once again we were excited to play today in front of our fans. We started well and scored. The tie was open but we conceded a goal in one action in the first half. After that it was complicated.
"I was very proud. We were brave and created chances and scored the second but could not get another. In the second half we played with energy."
Wembley woes still apparent for Spurs....
- Tottenham have won just one of their past eight matches at Wembley
- Mauricio Pochettino's side have conceded more goals in four European home games at Wembley this season (six) than they have in 12 Premier League games at White Hart Lane (five)
- Gent became the first Belgian side to eliminate English opposition in major European competition (excluding qualifiers) since Standard Liege knocked out Everton in the 2008-09 Uefa Cup.
- Spurs have been eliminated from eight of their past nine European knockout ties in which they have lost the first leg.
- Since the start of 2013-14, Harry Kane has scored four own goals - twice as many as any other Tottenham player.
Tottenham, who remain without a trophy since 2008, will focus their attention on trying to catch runaway Premier League leaders Chelsea.
Third-placed Spurs host Stoke City at White Hart Lane on Sunday (13:30 GMT).
- 15DierBooked at 85minsSubstituted forJanssenat 89'minutes
- 5VertonghenBooked at 64mins
- 2WalkerBooked at 74mins
- 12WanyamaBooked at 89mins
- 19DembéléSubstituted forWinksat 75'minutesBooked at 89mins
- 33DaviesSubstituted forSon Heung-minat 58'minutes
- 20AlliBooked at 39mins
- 7Son Heung-min
- 91KalinicBooked at 45mins
- 19DejaegereBooked at 23minsSubstituted forVerstraeteat 56'minutesBooked at 83mins
- 15SaiefBooked at 26mins
- 27SimonSubstituted forPerbetat 75'minutes
- 77MilicevicSubstituted forMattonat 45'minutes
- 7CoulibalyBooked at 89mins
- 29De Smet
- Jorge Sousa
- Shots on Target
Second Half ends, Tottenham Hotspur 2, KAA Gent 2.
Offside, KAA Gent. Kalifa Coulibaly tries a through ball, but Samuel Gigot is caught offside.
Attempt missed. Harry Kane (Tottenham Hotspur) right footed shot from the left side of the box is close, but misses to the right. Assisted by Jan Vertonghen.
Kyle Walker (Tottenham Hotspur) wins a free kick in the attacking half.
Foul by Kenny Saief (KAA Gent).
Corner, Tottenham Hotspur. Conceded by Thomas Foket.
Attempt blocked. Victor Wanyama (Tottenham Hotspur) left footed shot from the centre of the box is blocked.
Corner, Tottenham Hotspur. Conceded by Samuel Gigot.
Victor Wanyama (Tottenham Hotspur) is shown the yellow card.
Kalifa Coulibaly (KAA Gent) is shown the yellow card.
Substitution, Tottenham Hotspur. Vincent Janssen replaces Eric Dier.
Harry Winks (Tottenham Hotspur) is shown the yellow card.
Foul by Son Heung-Min (Tottenham Hotspur).
Anderson Esiti (KAA Gent) wins a free kick in the defensive half.
Attempt missed. Son Heung-Min (Tottenham Hotspur) right footed shot from the right side of the box is too high. Assisted by Harry Kane.
Foul by Victor Wanyama (Tottenham Hotspur).
Jérémy Perbet (KAA Gent) wins a free kick in the attacking half.
Eric Dier (Tottenham Hotspur) is shown the yellow card.
Foul by Eric Dier (Tottenham Hotspur).
Jérémy Perbet (KAA Gent) wins a free kick in the defensive half.
Harry Winks (Tottenham Hotspur) wins a free kick in the defensive half.
Foul by Thomas Matton (KAA Gent).
Corner, Tottenham Hotspur. Conceded by Anderson Esiti.
Louis Verstraete (KAA Gent) is shown the yellow card for a bad foul.
Kyle Walker (Tottenham Hotspur) wins a free kick on the right wing.
Foul by Louis Verstraete (KAA Gent).
Goal! Tottenham Hotspur 2, KAA Gent 2. Jérémy Perbet (KAA Gent) right footed shot from the centre of the box to the bottom right corner.
Hand ball by Anderson Esiti (KAA Gent).
Corner, Tottenham Hotspur. Conceded by Stefan Mitrovic.
Harry Winks (Tottenham Hotspur) wins a free kick on the right wing.
Foul by Jérémy Perbet (KAA Gent).
Attempt missed. Toby Alderweireld (Tottenham Hotspur) header from the centre of the box misses to the left. Assisted by Christian Eriksen with a cross following a corner.
Corner, Tottenham Hotspur. Conceded by Rami Gershon.
Substitution, KAA Gent. Jérémy Perbet replaces Moses Simon.
Substitution, Tottenham Hotspur. Harry Winks replaces Mousa Dembélé.
Kyle Walker (Tottenham Hotspur) is shown the yellow card for a bad foul.
Foul by Kyle Walker (Tottenham Hotspur).
Rami Gershon (KAA Gent) wins a free kick in the defensive half.
Hand ball by Anderson Esiti (KAA Gent).