And that final whistle could well signal the end of Burnley's stint in the Premier League. It's such a shame that it has come with a bit of a whimper today, but the Clarets were up against it from the 24th minute, when Michael Duff was dismissed for tripping Cheikhou Kouyatein in the area. Mark Noble's subsequent penalty was the difference maker.Head over to our overall live text for all the reaction.
- West Ham XI: Adrian, Jenkinson, Collins, Burke, Cresswell, Amalfitano, Noble, Kouyate, Nolan, Downing, Valencia. Subs: Jaaskelainen, Jarvis, Nene, O'Brien, Cole, Song, Oxford
- Burnley XI: Heaton, Trippier, Shackell, Duff, Mee, Boyd, Arfield, Jones, Taylor, Barnes, Ings. Subs: Gilks, Wallace, Kightly, Sordell, Reid, Jutkiewicz, Keane
Burnley now have some intent. But the long ball forward is dealt with and Ben Mee is forced into hacking down a marauding Stewart Downing.
Nene and Carlton Cole have been enthusiastically received by the Hammers support. Nene almost wriggles in on goal but is cut out. And then Cheikhou Kouyate hits a drive from 20 yards, which Jason Shackell nods off the line.
The chances are piling up for the home side. James Collins hooks over from a corner. It's quite disheartening to see Burnley unable to give this a real go.
Carl Jenkinson stretches his legs down the right side, not for the first time today. He has linked up with Stewart Downing to excellent effect. Burnley clear, but Carlton Cole finds himself with another tasty opening, but hits his shot straight at Tom Heaton.
In fact, when the chances do come, they are falling to West Ham. Carlton Cole, who has just come on for Enner Valencia, nods over a Stewart Downing cross. He should have done better.
Unfortunately for Burnley, this is drifting away. And that's no criticism of their effort. This has just been an impossible ask with 10 men.
Former Aston Villa striker Dion Dublin
"It's hard to see Burnley getting out of the relegation zone at this rate. QPR have given themselves a chance but Leicester have got momentum and will get out of it - Hull too. Sunderland are winning, and on current form Newcastle could be the ones to get sucked in as well."
Kevin Nolan, who has been the proverbial engine room for West Ham today, is off for Nene.
Burnley bring on Marvin Sordell, who replaces Ashley Barnes.
Elsewhere, Aston Villa are leading 3-1 against Everton. Sunderland are 2-1 up against Southampton. And QPR are level at 1-1 at Liverpool. The signs are not good Burnley fans.
The game has lost its zip, with West Ham prodding away with slow, patient build-up. Burnley briefly win it back, but Danny Ings is an isolated figure and watches the ball drift over his head.
Burnley need something. Anything. As it stands, they're just about keeping their heads above water, but West Ham keep coming and coming for that all important second goal.
Mark Noble's cross goes all the way to the back post and finds Reece Burke. Kieran Trippier is on hand to block the shot six yards out. Burnley are unable to find a way to put sustained pressure on the Hammers.
Ben Mee's right at the centre of things. He catches Kevin Nolan with a high boot - and the Hammers midfielder is a little displeased.
Former Aston Villa striker Dion Dublin
"To stay up you do need that bit of quality as well as the blood, sweat and tears. Burnley have been lacking in quality, and they've been picked off in their general play. Just get a point today. Although they were unlucky to have Michael Duff sent off when there were players covering."
This Stewart Downing dive/penalty claim. You can watch from six different angles and come up with six different opinions. Downing has to hurdle he tackle - but does he have to hit the deck?
Ouch. Cheikhou Kouyate has taken one down the back of the leg from Michael Keane, who gets a yellow card.
Hmmm. Stewart Downing has dived, apparently. The winger is flying into the area, and Ben Mee comes sliding across.
There is contact, but is Downing expecting it? It's either a penalty or a dive - John Moss has gone with dive.
West Ham come close. Kevin Nolan's poked ball through finds Morgan Amalfitano, and the Frenchman drifts an effort wide.
At the other end, Matty Taylor's low drive is kept out by Adrian.
And, it's all gone a bit bonkers now, as Tom Heaton saves from Kevin Noland and Enner Valencia can't put in the rebound.
And when things aren't going for you, they're not going for you. Carl Jenkinson bundles over Danny Ings on the edge of the area - no free-kick, says Jonathan Moss.
I've had another look at Michael Duff's red card. Scott Arfield looks like he is right there to challenge Kouyate - it's really, really harsh.
Danny Ings has a chance of his own making, but can't make it count. The Clarets' top scorer injects a bit of pace into his stride and comes off the touchline, into the area, and shoots wide.
Burnley manage to free Ashley Barnes down the right channel. But he's dinked ball into the middle is safely grasped by Adrian. West Ham carry the ball with purpose straight up the other end, but Stewart Downing also hits the keeper with his cross.
It's worth noting that Downing has been terrific today, always wanting the ball down the right flank.
It doesn't seem to have made too much difference. Kevin Nolan has space at the near post and flicks goalwards, but it's just wide.
Burnley will have a reshuffle for the second half, as they attempt to deal with Michael Duff's red card.
George Boyd is the man to make way, with Michael Keane coming to slot into the back four.
Jamie has enlightened me as to who Mr Moo is, the name referred to on the Hammers PA system.
Jamie Kanawaty: It's "Mr Moon" which is a security code for the WHU officials
As it all stands, Burnley are a whopping eight points off safety, with just three more games to come after this. Even my most basic of maths suggests that anything but wins for Burnley and defeats for the teams above them would spell relegation, if things stay as they are.
The reason the gap has potentially increased is because Aston Villa are leading Everton 2-0 and Sunderland are drawing with Southampton.
In a small glimmer of hope for the Clarets, QPR are losing at Liverpool.
Where do Burnley go from here? They must feel like the world is against them at the moment.
After last week's drama of Matty Taylor missing a penalty and Leicester scoring their winner 59 seconds later, it is a controversial red card that has them in a muddle this week.
Kieran Trippier hits a free-kick over the West Ham bar, before Aaron Cresswell has a crack from distance at the other end, with the same result. And that will be that for the first half.
The PA system has just made a curious announcement at Upton Park.
"Could the secretary be aware that Mr Moo is in the ground."
Anyone? No, me neither.
Try telling Mark Noble that Sam Allardyce isn't worth playing for. He really enjoyed that penalty.
He probably didn't enjoy the booking he has just received for catching Scott Arfield.
Enner Valencia is in the thick of it, isn't he? Well, now he's in the book after catching Danny Ings with his elbow in an aerial challenge.
Burnley are forced into a bit more panicked defending. But Enner Valencia is offside, so the Clarets can breathe easy.
Now we've got a chance to breathe, we can have a closer look at Michael Duff's sending off.
It's not your classic last-man scenario, with Cheikhou Kouyate through on goal. Instead the Hammers man has jinked into the area and drawn a foul from Duff.
He was likely about to pull the trigger - so has Duff denied a goal-scoring opportunity? Referee Jonathan Moss says, "yes".
Munch Veevers: In what world, nay, dimension, was that a red card for Michael Duff? Burnley really are the unluckiest team in the Premier League.
Agubata Odinaka: Harsh red card to Duff for me...now West Ham will go on to get a draw in a match they would have certainly lost as usual
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There's some hope for Burnley. Kieran Tripper crosses in from a corner and Ashley Barnes connects with a good header, but Adrian is equal to it. It looks like the Hammers keeper may have used a bit of thigh to keep it out - as long as he gets the job done.
Elsewhere, Burnley's relegation rivals Sunderland were 1-0 up on Southampton after Jordi Gomez's penalty. But the lead lasted barely a minute, with Sadio Mane equalising.
Tom Heaton is at it again, touching Morgan Amalfitano's half-volley around the post. Burnley need to get organised, and they need to do it quickly.
It should be 2-0 to West Ham. Enner Valencia receives the ball 10 yards out from Stewart Downing's pass and clips it towards goal, but it's a terrific save by Tom Heaton. The 10 men of Burnley are shell shocked.
Duff was done all ends up by Kouyate, who cut back in on to his right foot and was caught by the Burnley man.
Mark Noble makes no mistake from the spot.