Wigan Warriors coach Shaun Wane has kept faith with the same group selected for the 24-20 win over Warrington.
Whoever loses the match will still be able to reach the Grand Final via the elimination play-offs.
Huddersfield Giants are still unable to call on the services of half-back Danny Brough (groin) so Jake Connor is likely to retain his place.
Full-back Scott Grix (groin) and prop Eorl Crabtree (knee) both make their returns for the visitors.
Huddersfield won at defending champions Wigan in the opening game of the 2014 season back in February, with Giants winger Jermaine McGillvary scoring a hat-trick of tries in a 24-8 victory.
Wigan Warriors: Bateman, Bowen, Burgess, Charnley, Clubb, Crosby, Dudson, Farrell, Flower, Gelling, Green, Hughes, McIlorum, O'Loughlin, Pettybourne, Powell, Sarginson, Smith, Tomkins.
Huddersfield Giants: Grix, McGillvary, Cudjoe, Wardle, Murphy, Robinson, Crabtree, Lunt, Kopczak, Ferres, Bailey, Lawrence, Patrick, Faiumu, Ta'ai, Broughton, Kaufusi, Johnson, Connor.