Newport Gwent Dragons recall four players and make a positional switch to host Ulster in the Pro12 on Friday.
Carl Meyer comes in at full-back, Tom Prydie goes to left wing, Adam Hughes returns at left wing with lock Nick Crosswell and hooker Rhys Buckley also back.
Ulster have made four changes with Iain Henderson, Sean Reidy, Andy Warwick and Darren Cave coming in.
Ulster go into the round fourth in the table with Dragons 10th.
Robbie Diack, Jacob Stockdale and Callum Black drop to the Ulster bench while back row Marcell Coetzee was injured in the win over Zebre a fortnight ago and is sidelined for four months.
Jared Payne and Henderson come into the starting line-up after playing in Ireland's Six Nations win over England last weekend.
Stuart Olding continues at fly-half after impressing in the playmaker role against Zebre, with regular first-choice number 10, Paddy Jackson, primed to enter the fray from the replacements' bench.
Luke Marshall is set to win his 100th Ulster cap, a little over six years since the centre made his debut against Munster.