Wasps welcome back fit-again centre Kyle Eastmond for the first time this season as they play host to Newcastle.
Gabiriele Lovobalavu and Kearnan Myall are also back for Wasps, who are without nine injured players, as well as England internationals Elliot Daly, Nathan Hughes and Joe Launchbury.
Newcastle have flanker Gary Graham making his Premiership debut.
He is the son of former Scotland prop George Graham, who helped Newcastle win the Premiership in 1998.
French centre Maxime Mermoz also makes his first league start for the Falcons, while Simon Hammersely returns from injury, with Alex Tait switching to the wing.
Rugby league convert Eastmond makes his first start since for Wasps rupturing his Achilles against Gloucester at the end of February.
While Lovobalavu (calf) and Myall (ankle) are both fit too, Ashley Johnson is made captain on his 150th appearance for the club.