Florence Welch, of Florence and the Machine, was a double-winner at the Q Awards in London taking best female and best track for You've Got The Love.
Take That also made their first public appearance since Robbie Williams rejoined them in July.
The band, whose comeback single, The Flood, and new album, Progress, are both due out next month, won the magazine's hall of fame award.
Kasabian were named best act in the world.
Take That, who were sneaked into the awards to avoid the red carpet, were led on stage by Gary Barlow to collect their award.
In their acceptance speech, Williams hinted that the band might be back for good.
"Very happy to be back - first day and we've won an award," he said. "I'd like to thank my boys. Extremely happy here. Looking forward to the next few years."
Another newly reformed band - Suede - picked up the Q inspiration award.
Singer Brett Anderson paid tribute to their original guitarist, Bernard Butler, who quit the line-up in 1994 during the recording of second album Dog Man Star.
"I don't think we can accept this award without mentioning Bernard and that great work he did with us early on. This one's for Bernard too."
He later described Suede's reunion in 2010 as "temporarily permanent".
Surprise winner of best album was High Violet, the fifth release by New York band The National.
Singer Matt Berninger told the BBC: "It was weird and surreal and fun to see so many heroes in the same room. It felt as though we were plopped into an alternative universe for an hour there."
The National beat Arcade Fire, Green Day, Kings of Leon and Muse to the best album prize.
Berninger joked: "We are looking forward to rubbing it into Arcade Fire's nose as soon as we see them!"
Paolo Nutini picked up best male and Bryan Ferry was named the Q icon.
Best new act went to folk band Mumford and Sons while US rockers Green Day won the live award.
Best video went to End Credits, by Chase and Status featuring Plan B, who also won best breakthrough act.
Plan B said the award was a surprise, adding: "I expect the worst, I expect people to ignore me and be down on me because that is what I've experienced. I'm a little bit unaware of how big it has got until other people make me aware of it."
The Q classic album went to Band on the Run, by Wings. Sir Paul McCartney dedicated his award to late wife Linda who died in 1998 from cancer, who co-wrote and played on the album.
Meanwhile, the innovation in sound award went to super-producer Mark Ronson. Duran Duran's Nick Rhodes, who presented the award, said Ronson was a deserving recipient.
"Having worked with him over the last 18 months, he's pretty extraordinary in the studio and has an enthusiasm and a willingness to experiment that you don't find in many modern producers."
There were also awards for other long-established acts including Madness, The Chemical Brothers, and Crowded House's Neil Finn.
Suggs, of Madness, joked the band had been "idle" for 30 years and that they were being rewarded for the laziness.
Other stars who attended the event at London's Grosvenor House Hotel included Nadine Coyle, Charlotte Church, Ray Davies, Corrine Bailey Rae, Sandie Shaw, Bernard Sumner and KT Tunstall.
Singer Clare Maguire, 22 - currently on tour with Plan B - was tipped as the next big thing.