Alec Baldwin, Kylie Minogue and Janet Jackson are to support a gala dinner and auction at the Cannes Film Festival to raise money for Aids research.
The annual event, held by the American Foundation for Aids Research (Amfar), was passionately supported by the late actress Elizabeth Taylor.
Baldwin, who stars in the hit comedy 30 Rock, is among the celebrity "co-chairs" for the night on 24 May.
Amfar has raised more then $70m (£44m) since launching in Cannes in 1993.
The non-profit organisation is dedicated to supporting Aids research and HIV prevention and education.
Other co-chairs at the Cinema Against Aids event will include The Artist's Oscar-winning director Michel Hazanavicius and leading lady Berenice Bejo.
Actress Milla Jovovich, designer Karl Lagerfeld, film producer Harvey Weinstein and Bollywood star Aishwarya Rai will also take part.
Stars will be expected to dig deep during a live auction and runway show.
Five years ago, Kylie Minogue performed some of her hit singles at the event alongside actress Sharon Stone.