Covid-19: Seven UK blood clot deaths after AstraZeneca vaccine

By James Gallagher
Health and science correspondent

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Image source, EPA

Seven people have died from unusual blood clots after getting the Oxford-AstraZeneca vaccine in the UK, the medicines regulator has confirmed to the BBC.

In total, 30 people out of 18 million vaccinated by 24 March had these clots.

It is still not clear if they are just a coincidence or a genuine side effect of the vaccine.

The Medicines and Healthcare Products Regulatory Agency says the benefits continue to outweigh any risk.

The World Health Organization and the European Medicines Agency have echoed this conclusion.

A spokeswoman for AstraZeneca said: "Patient safety remains the company's highest priority."

However, concern has led to other countries including Germany, France, the Netherlands and Canada to restrict the vaccine's use only to older people.

The data released by the MHRA on Friday showed 22 cases of cerebral venous sinus thrombosis (CVST) which is a type of blood clot in the brain.

These were accompanied by low levels of platelets, which help form blood clots, in the body. The MHRA also found other clotting problems alongside low platelet levels in eight people.

Now the MHRA has confirmed, in an email to the BBC, that "sadly seven have died".

Dr June Raine, the chief executive of the MHRA, said: "The benefits… in preventing Covid-19 infection and its complications continue to outweigh any risks and the public should continue to get their vaccine when invited to do so."

Investigations are under way to determine if the AstraZeneca vaccine is causing the very rare blood clots. Earlier this week the European Medicines Agency said it was "not proven, but is possible".

Two issues are raising suspicions. The first is the unusual nature of the clots which, including low levels of platelets and rare antibodies in the blood that have been linked to other clotting disorders.

"This raises the possibility that the vaccine could be a causal factor in these rare and unusual cases of CVST, though we don't know this yet, so more research is urgently needed," said Prof David Werring, from the UCL Institute of Neurology.

The other issue is the difference between the Oxford-AstraZeneca and the Pfizer-BioNTech vaccines.

There have been two cases of CVSTs after Pfizer in the UK, out of more than 10 million vaccinated, but these did not have the low platelet levels.

However, there remains uncertainty around how common these clots normally are. Estimates range from two cases per million people every year to nearly 16 in every million in normal times and the coronavirus has been linked to abnormal clotting, which may be making these clots more common.

Germany has reported 31 CVSTs and nine deaths out of the 2.7 million people vaccinated there, with most cases in young or middle-aged women.

Similar data on who has been affected in the UK has not been published in the UK, but a wider mix of people are thought to have been affected.


All medicines, from vaccines to paracetamol, have the potential to cause severe side effects.

The seasonal flu jab has around a one-in-a-million chance of causing the nerve disorder Guillain-Barre syndrome.

So, the real question is: Are the risks worth the benefits?

Even if the vaccine was the cause, and this is still not proven, the numbers suggest around one death in every 2.5 million people vaccinated.

However, this has to be weighed against the known threat posed by coronavirus.

If 2.5 million 60-year-old people caught coronavirus then around 50,000 would die. If they were all 40-year-olds then around 2,500 would die.

This balance of risk and benefit will continue to be assessed as more safety data comes in and as the vaccine programme moves into younger people, who are at lower risk of dying from Covid-19.

One scientist has told the BBC that evidence is growing that the blood clot events are "causally related", although he stressed that the benefits of taking the AstraZeneca vaccine still far outweighed the risks of not getting the jab.

Prof Paul Hunter, a medical microbiologist at the University of East Anglia, told BBC Radio 4's Today programme: "It is not uncommon to get clusters of rare events purely by chance.

"But, once you find that cluster in one population and it then crops up in another - such as previously in the German and now in the English - then I think the chances of that being a random association is very, very low.

"Clearly more work needs to be done, but I think the evidence is shifting more towards it being causally related at the moment."

However, public health expert Prof Linda Bauld, of the University of Edinburgh, told BBC Breakfast the cases were "rare events" and stressed there was no event "at the moment of a causal link - that the vaccine would be directly causing these outcomes".

She urged the public to continue coming forward for a jab, and added: "Covid itself increases the risk of blood clots quite significantly and it's possible that that may be part of the explanation why we're seeing this."

Media caption,
Covid vaccine safety: How does a vaccine get approved?

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