A man died and another was seriously hurt in a crash on the A45 at Flore.
It happened at about 07:15 yesterday between the Nether Heyford junction and the Holiday Inn.
Police said a dark blue BMW 5 series, travelling towards the M1, collided with a white Ford Focus travelling in the opposite direction.
The driver of the Focus, a 26-year-old man from Rugeley in Staffordshire, died at the scene.
The BMW driver, a 27-year-old man from Wembley, was taken by air ambulance to University Hospital Coventry with serious injuries.
Witnesses have been asked to contact police.