Supporters of a second referendum may well use the night's results to push their case, according to Georgia Roberts of BBC Westminster.
She said the leave parties such as the Brexit Party and UKIP got around 35% of the votes while remain parties like the Liberal Democrats and Greens got about 40%.
Ms Roberts said: "Based on that plenty of people around Westminster will be making the case for a second referendum."
But Dr Chris Fear said the results are "much more ambiguous" than the 2016 referendum and votes for the two main parties confuse the issue as they do not give clear indication either way.
He said: "What do you with do with all those votes for Labour and Conservatives? If you try to factor them in then I think people will see exactly what they want to see."
UK PM and opposition leader lose at home
If you want an indicator of how difficult this election has been for Britain's two largest parties, look to the leadership.
Prime Minister Theresa May's Conservative Party came third in her own constituency - losing to the Brexit Party and Liberal Democrats.
And her opposite number, Jeremy Corbyn of the Labour Party, saw his party come second to to the Liberal Democrats - and it was his birthday on Sunday, too.
EPACopyright: EPA
Tories worst performance since 1832
Laura Kuenssberg
BBC political editor
We shouldn't forget how appalling this night is for the Tories.
This is their worst performance as a party going back to 1832.
If this was a first-past-the-post election, they would not have taken a single seat.
Voters treated election as a referendum
James Vincent
Political Editor BBC Look North
This
was an election. But many treated it as a referendum.
The numbers will be added up by
parties on either side to determine whether "the Brexit vote" is as strong in
Yorkshire and Humber as it was in 2016.
But what we do know is that the
Brexit Party dominated. Labour had two MEPs, it now has one. The Conservatives
lost both of theirs.
The Lib Dems and the Greens
will look at their first MEPs here and say that it proves remainers don’t want
the two main parties.
The Brexit Party will say
exactly the same about leavers.
Labour and the Conservatives
have big problems telling people in Yorkshire what their Brexit plan is.
In Sheffield Labour were beaten
into 4th place and they weren’t even the top choice in Doncaster, where the
party was born.
European Elections 2019: North West results
Video content
Video caption: European Elections 2019: North West resultsEuropean Elections 2019: North West results
The declaration of results from the North West region in the European Elections.
Widdecombe: I heard the howl of duty
Ann Widdecombe, who was elected for the Brexit party in the South West, said she heard the "howl of duty" to return to front-line politics after nine years out.
The former Conservative MP said the success of the Brexit Party, which won 26 seats six weeks after being formed, was down to them giving voters a "clear choice".
She said the Conservatives and Labour had "confused" people but the Brexit Party only had one item in the agenda - leaving the EU.
ReutersCopyright: Reuters
Ms Widdecombe said: "We've got one question so we can get one answer and boy haven't we got it.
"We never wanted these elections, they are a demonstration of the total farce that has taken over at Westminster.
"Given we have had them we will play our role in the EU parliament and we will set about delivering Brexit."
Dr Chris Fear said the Brexit Party should be seen as a "single-issue pressure group".
How are the seats being allocated?
England's seats in the European Parliament are distributed according to the D'Hondt system, a type of proportional representation.
Parties vying for election submit a list of candidates to voters in each region.
A system devised by Victor D'Hondt, a Belgian lawyer and mathematician active in the 19th Century, dictates the results:
In the first round of counting the party with the most votes wins a seat for the candidate at the top of its list
In the second round the winning party's vote is divided by two, and whichever party comes out on top in the re-ordered results wins a seat for their top candidate
The process repeats itself, with the original vote of the winning party in each round being divided by one plus their running total of MEPs, until all the seats for the region have been taken
Live Reporting
Duncan Leatherdale
All times stated are UK
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BBCCopyright: BBC 

EPACopyright: EPA 

Video caption: European Elections 2019: North West resultsEuropean Elections 2019: North West results 
ReutersCopyright: Reuters -
In the first round of counting the party with the most votes wins a seat for the candidate at the top of its list
-
In the second round the winning party's vote is divided by two, and whichever party comes out on top in the re-ordered results wins a seat for their top candidate
-
The process repeats itself, with the original vote of the winning party in each round being divided by one plus their running total of MEPs, until all the seats for the region have been taken
Latest PostFormer lads mag editor elected MEP
The Brexit Party wins three seats, with one each for Labour, the Conservatives, Greens and Lib Dems.
Read moreBrexit Party dominates in EU elections
The Lib Dems also see a surge in support, while the Tories and Labour suffer heavy losses, as voters split along Leave and Remain lines.
Read moreThe UK's results in maps and charts
Find results for your area and follow the others as they come in.
Read moreRees-Mogg elected Brexit Party MEP
The Conservatives and UKIP lost all of their seats with the Brexit Party top in the East Midlands.
Read moreFarage re-elected in the South East
Brexit Party leader Nigel Farage says he is getting ready for a general election.
Read moreBrexit Party wins half of Yorkshire seats
The Lib Dems and Green Party both also gained a seat each in the region.
Read moreLib Dems top London European vote
The Conservatives and UKIP lose their London MEPs, but Labour, Brexit and Greens all take seats.
Read moreNew MEP Widdecombe warns of 'carnage'
Former MP Ann Widdecombe wins one of three seats for the Brexit Party.
Read moreLib Dems and Greens gain in the East
The Brexit Party wins three seats in the EU elections, with the Lib Dems and Greens overtaking Labour.
Read moreGood night (or should that be good morning?)
Duncan Leatherdale
BBC News Online
That's all for our coverage of the EU election results across England.
Thanks so much for joining us.
In short, the Brexit Party had a good night winning almost half of the 60 seats.
Remain supporters say they also did well when you combine the votes for remain-supporting parties such as the Liberal Democrats and the Greens.
But it wasn't a good night for the Conservatives or Labour.
One thing I hope we can all agree on though - it's time for bed.
North East MEP in clean break call
Labour holds on to one of its seats but loses the other.
Read more'Our worst ever result' - Tory MEP
"This is our worst-ever result," says Daniel Hannan, who has been re-elected as a Conservative MEP.
"We need to make Brexit happen, but in a way that will carry the 48% with us," he says.
He adds that his party now needs "different, credible leadership" to ensure Brexit is delivered.
Brexit Party wins three North West seats
Labour and the Lib Dems won two seats each while the Green Party gained one.
Read moreDoes election make second referendum case?
Supporters of a second referendum may well use the night's results to push their case, according to Georgia Roberts of BBC Westminster.
She said the leave parties such as the Brexit Party and UKIP got around 35% of the votes while remain parties like the Liberal Democrats and Greens got about 40%.
Ms Roberts said: "Based on that plenty of people around Westminster will be making the case for a second referendum."
But Dr Chris Fear said the results are "much more ambiguous" than the 2016 referendum and votes for the two main parties confuse the issue as they do not give clear indication either way.
He said: "What do you with do with all those votes for Labour and Conservatives? If you try to factor them in then I think people will see exactly what they want to see."
UK PM and opposition leader lose at home
If you want an indicator of how difficult this election has been for Britain's two largest parties, look to the leadership.
Prime Minister Theresa May's Conservative Party came third in her own constituency - losing to the Brexit Party and Liberal Democrats.
And her opposite number, Jeremy Corbyn of the Labour Party, saw his party come second to to the Liberal Democrats - and it was his birthday on Sunday, too.
Tories worst performance since 1832
Laura Kuenssberg
BBC political editor
We shouldn't forget how appalling this night is for the Tories.
This is their worst performance as a party going back to 1832.
If this was a first-past-the-post election, they would not have taken a single seat.
Voters treated election as a referendum
James Vincent
Political Editor BBC Look North
This was an election. But many treated it as a referendum.
The numbers will be added up by parties on either side to determine whether "the Brexit vote" is as strong in Yorkshire and Humber as it was in 2016.
But what we do know is that the Brexit Party dominated. Labour had two MEPs, it now has one. The Conservatives lost both of theirs.
The Lib Dems and the Greens will look at their first MEPs here and say that it proves remainers don’t want the two main parties.
The Brexit Party will say exactly the same about leavers.
Labour and the Conservatives have big problems telling people in Yorkshire what their Brexit plan is.
In Sheffield Labour were beaten into 4th place and they weren’t even the top choice in Doncaster, where the party was born.
European Elections 2019: North West results
Video content
The declaration of results from the North West region in the European Elections.
Widdecombe: I heard the howl of duty
Ann Widdecombe, who was elected for the Brexit party in the South West, said she heard the "howl of duty" to return to front-line politics after nine years out.
The former Conservative MP said the success of the Brexit Party, which won 26 seats six weeks after being formed, was down to them giving voters a "clear choice".
She said the Conservatives and Labour had "confused" people but the Brexit Party only had one item in the agenda - leaving the EU.
Ms Widdecombe said: "We've got one question so we can get one answer and boy haven't we got it.
"We never wanted these elections, they are a demonstration of the total farce that has taken over at Westminster.
"Given we have had them we will play our role in the EU parliament and we will set about delivering Brexit."
Dr Chris Fear said the Brexit Party should be seen as a "single-issue pressure group".
How are the seats being allocated?
England's seats in the European Parliament are distributed according to the D'Hondt system, a type of proportional representation.
Parties vying for election submit a list of candidates to voters in each region.
A system devised by Victor D'Hondt, a Belgian lawyer and mathematician active in the 19th Century, dictates the results:
Click here to read more about how the system works.