There were no Covid-related deaths at either of Nottinghamshire's two main hospital trusts in the week up to the 21 April, health bosses say.
The last time there were seven days without Covid deaths at Nottingham University Hospitals Trust (NUHT) or Sherwood Forest Hospitals Trust (SFHT) was between 5-11 September.
Amanda Sullivan, interim executive at the two trusts, said: "It’s a tremendous psychological boost for those people working in our hospitals, to see the results of the vaccination programme, the reduction in rates and the impact of the lockdown coming to fruition.
"Seeing the benefits of all that with far fewer people coming into hospital is a tremedous boost for those staff."
Since the start of the pandemic there have been 1,713 Covid deaths in Nottinghamshire.