The American space agency Nasa will attempt to put another robotic probe on Mars later.
The InSight lander is being targeted at a flat plain just north of the planet's equator called Elysium Planitia.
It carries a suite of instruments - many of them from Europe - to try to determine the rocky world's internal structure.
Signals from the probe confirming its safe touchdown should be received at 19:53 GMT, give or take a minute.
As with previous surface missions, InSight must survive the "seven minutes of terror" - the time it takes for a probe entering Mars' thin atmosphere at hypersonic speed to slow to walking pace and gently put itself on the ground.
Many have tried; most have failed. "As humanity, as explorers - we're batting at less than 50%," said Nasa's science chief, Thomas Zurbuchen. "Going to Mars is really, really hard."
How will InSight fare?
InSight has some heritage on its side. It will be using the exact same combination of heatshield, parachute and retro-rockets that proved so successful in positioning Nasa's Phoenix probe in Mars "Arctic" in 2007.
Engineers here at mission control on the Jet Propulsion Laboratory campus in California have a quiet confidence in the outcome as a result. That said, they are also very aware of the statistics.
"We've done all the preparations that we can possibly think of to make sure that our entry, descent and landing (EDL) goes as smoothly as we can imagine," explained project manager Tom Hoffman. "But Mars as a planet does not always behave. I think our team is ready; I think the spacecraft is ready. We just don't know if Mars is ready," he told BBC News.
What is the latest status?
The EDL engineers have been closely watching the weather on the Red Planet, looking especially for any dust storms and evidence of high winds that could complicate InSight's passage through the atmosphere.
The probe's trajectory was altered ever so slightly on Sunday, to ensure it is lined up perfectly with the targeted landing zone on Elysium Planitia.
There is very little now that Nasa teams can do to influence the outcome. The whole process is necessarily automated because commands take eight minutes to traverse the 146 million km distance between Mars and Earth. You cannot use a joystick to control a far-off probe.
InSight will transmit messages as it heads down to the surface. These will be relayed back to Earth via two small satellites flying overhead. Radio telescopes at Earth will also be tracking the probe's progress just in case the primary communications link falls over.
Assuming it lands in one piece, InSight is programmed to take a quick picture of its immediate surroundings. This could come back within the first 30 minutes on the surface.
What is different about this mission?
This will be the first probe to dedicate its investigations to understanding Mars' interior.
Scientists want to know how the world is constructed - from its core to its crust. InSight has three principal experiments to achieve this goal.
The first is a package of Franco-British seismometers that will be lifted on to the surface to listen for "Marsquakes". These vibrations will reveal where the rock layers are and what they are made of.
A German-led "mole" system will burrow up to 5m into the ground to take the planet's temperature. This will give a sense of how active Mars still is.
And the third experiment will use radio transmissions to very precisely determine how the planet is wobbling on its axis. Deputy project scientist Suzanne Smrekar uses this analogy: "If you take a raw egg and a cooked egg and you spin them, they wobble differently because of the distribution of liquid in the interior. And today we really don't know if the core of Mars is liquid or solid, and how big that core is. InSight will give us this information."
Why do we need to know this?
Scientists understand very well how Earth's interior is structured, and they have some good models to describe the initiation of this architecture at the Solar System's birth more than 4.5 billion years ago. But Earth is one data point and Mars will give researchers a different perspective on how a rocky planet can be assembled and evolve through time.
InSight chief scientist Bruce Banerdt said: "The small details in how planets evolve are what we think make the difference between a place like Earth where you can go on vacation and get a tan, and a place like Venus where you'll burn in seconds or a place like Mars where you'll freeze to death."