The two resignations come a week after Mark Zuckerberg outlined plans for a "privacy-focused" platform.Read more
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The boss of Instagram is due to meet the health secretary today over the platform's handling of content promoting self-harm and suicide.
It comes after links were made between the suicide of teenager Molly Russell and her exposure to harmful material.
Molly, 14, took her own life in 2017. When her family looked into her Instagram account they found distressing material about depression and suicide.
Her father told the BBC he believed the Facebook-owned platform had "helped kill my daughter".
Instagram has previously said it doesn't automatically remove distressing content because it had been advised by experts that allowing users to share stories and connect with others could be helpful for their recovery.