Just 100 people will attend the mass, as Italy enters a strict lockdown today
The BBC's Quentin Somerville gets to see the Sistine Chapel without the crowds.
Pope Francis calls for global solidarity with a mass held behind closed doors on Easter Sunday.
A small number of worshippers attended the mass, while observing social distancing.
The service usually only happens twice a year but was given as Italy's coronavirus death toll passes 9,000.
Due to the threat of coronavirus, Pope Francis delivers his weekly blessing via videolink to avoid large crowds gathering in the Vatican.