Allegations of sexual abuse made by school pupils on a website are "shocking and abhorrent", Education Secretary Gavin Williamson has said.
No school should be a place "where young people feel unsafe" or where abuse could take place, he added.
Mr Williamson pledged to take "appropriate action", and urged victims to tell someone they trusted.
The website Everyone's Invited has recorded 8,000 testimonies of sexual abuse from pupils.
It was set up last year as a place where victims can post anonymous accounts of abuse they have suffered.
Many of the accounts describe allegations of sexual harassment and sexual violence carried out against young women by young men who are at school or college or university with them, or part of the same social groups.
Independent schools such as Highgate School and Dulwich College are among those that have said they will take action following the online allegations, but the site's founder Soma Sara said "rape culture" was a problem for all schools.
Mr Williamson said on Twitter: "No school - whether an independent school or state school - should ever be an environment where young people feel unsafe, let alone somewhere that sexual abuse can take place.
"The allegations that I have heard in recent days are shocking and abhorrent.
He said any victim of "these sickening acts" should raise their concerns with someone they trusted, such as a teacher, family member or the police. "We will take appropriate action," he said.
The government has said it is very concerned by the "significant" number of allegations.
Most schools, colleges and universities took safeguarding responsibilities seriously, but it was "particularly shocking" to hear these allegations made about places of education "where everyone should feel secure and be protected", a government spokesman said.
The Department for Education, the Home Office and the National Police Chiefs' Council were in touch with the Everyone's Invited website to provide support, protection and advice, he added.
Police and the government have also said a helpline will be set up to allow victims to access support.
Robert Halfon, who chairs the House of Commons education select committee, said the Everyone's Invited website was "pretty grim" reading and he called for an investigation.
"Your heart goes out to all the people who have suffered the abuse, the sexual harassment, the threats, the abuse online," said Mr Halfon.
"I do think there is a Lord of the Flies culture in some of our schools across our country, and what needs to happen is an urgent inquiry to overhaul safeguarding procedures because they are not fit for purpose."
Labour leader Sir Keir Starmer said: "There's got to be an inquiry and it has got to get going very fast, this is serious."
He also called for "cultural change in terms of behaviour in our schools and in our young people, but also in the respect that is shown particularly for women and girls".
Jess Phillips, Labour's shadow minister for safeguarding, said ministers had failed to act on "most" recommendations put forward following a 2016 inquiry into sexual harassment in violence and schools.
"We need a better inspection regime, we need to have a proper inquiry, we need the government to actually be collecting the data - they're not actually currently collecting this data anywhere," she told BBC Breakfast.
"Whilst I don't think that we should be criminalising every single person who makes an inappropriate joke to a woman, I do think it should be part of every single school's disciplinary proceedings," she added.
Ms Sara told the BBC that allegations on the site included "sexual harassment, groping at a Christmas party, image-based abuse, revenge porn, non-consensual sharing of intimate photos - and just general sexism and misogyny".
"These are stories of rape culture - so where behaviour that's not normal is normalised," she said.
Anonymous testimonies listed on the site do not reveal the identity of the pupils or their attackers, but many schools are named.
Highgate School, among the private schools caught up in the claims, says it is launching an "immediate external review of the sexual abuse and harassment allegations" and is "working on an anti-sexism plan".
Dulwich College's head teacher Joe Spence said: "The behaviour described is distressing and entirely unacceptable" and "we are meeting with victims to listen to their experiences and their concerns, and we will act on them".
The website initially drew attention to private schools, particularly in London, but Ms Sara, who is now 22, said that was a consequence of her own background - and that the range of testimonies, from state and private schools, showed this was a much wider issue.
Many of the incidents recounted took place outside school or university premises, however.
Paul Whiteman, leader of the National Association of Head Teachers, said school leaders had to "ask ourselves what more we can all do to prevent sexual harassment and violence" - but he said "this is a problem that reaches far beyond the school gates".
Norfolk Chief Constable Simon Bailey blamed the "volume of pornographic material that's being consumed".
"There's an erosion of an understanding of what normal sexual relationships look like," said the National Police Chiefs' Council lead on child protection.