Flood defences are being deployed and roads closed due to ongoing rainfall.
Defences against the River Severn have gone up in Frankwell, Shrewsbury; while defences in Coleham Head are due to go up at 18:00 GMT.
It comes as a severe flood warning, meaning a danger to life, has been put in place for the town.
The number of warnings in which flooding is expected in England now stands at 85, along with a further 174 flood alerts.
River levels in Shrewsbury are expected to be the highest seen in 20 years, the Environment Agency said.
We will be deploying more flood defences in #Shrewsbury soon.— Dave Throup (@DaveThroupEA) February 23, 2020
Flood warning issued for town and we now expect levels to exceed those seen last week. These will be the highest seen in 20 years.
Some property flooding and significant disruption is expected. pic.twitter.com/wmkYRr55dY
Elsewhere in Shropshire, Shrewsbury Fire Station said its water rescue unit and boat crew had been in the Melverley area checking on vulnerable people and those who had been isolated by the flood water.
Wellington Fire Station tweeted that the road between Atcham and Cross Houses was closed due to flooding.
There has also been flooding in the south of the county. Jade Copeland, manager of the White Horse Inn, Clun, said: "The amount of rain we have had has, unfortunately, brought the river back out.
"It is still rising and by the looks of it, it is going to become a lot worse."
Shropshire Council has enacted its severe weather emergency protocol to provide accommodation to rough sleepers.
It said it would update residents on the flooding situation as it developed.
In Herefordshire, the B4530 Adforton to Walford is closed due to flooding.
Herefordshire and Worcestershire Fire Service crews were also sent to rescue two vehicles from floodwater in Leintwardine.
11:36 📟🚨sent to a car stuck in flood at Leintwardine. 2 persons rescued by @HWFireTenbury using their sled. Then both crews were sent to another vehicle in flood water on a closed road. Please don't drive past Road Closed signs, you might not be covered by your car insurance. pic.twitter.com/ZGdXitauhs— HWFire Kingsland (@HWFireKingsland) February 23, 2020
In Worcestershire, the Hanley Road out of Upton-upon-Severn was closed. In Worcester there is said to be the possibility "of exceptionally high levels by midweek", higher than those in the aftermath of Storm Dennis.
And at Trescott Ford, in south Staffordshire, police said a vehicle had become stranded in flood water.
#ROADCLOSURE | Due to recent weather, #Trescott Ford is still impassable as we await recovery for another vehicle which has attempted to pass through. (and failed!) ⚠️ Find an alternative route whilst water levels remain high. 👮🏼♂️👍🏼 pic.twitter.com/0Mbe7pSUB0— South Staffs Police (@SStaffsPolice) February 23, 2020
Met Office forecaster Marco Petagna said Sunday should see a short respite from the more stormy conditions but warned of a fresh wave of bad weather overnight.
The weather is expected to settle down over Tuesday and Wednesday, although the Met Office said further heavy rain was expected later in the week.
An Environment Agency spokesman said the further rain meant the "flood risk continues, with the impacts of stormy weather continuing to be felt across England".
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