Parts of Luton town centre will be closed for the international carnival on Bank Holiday Monday.
The event, which is Britain's biggest one-day carnival, is expected to attract more than 100,000 visitors.
The procession leaves at 1330 BST from Wardown Park and will make its to the New Bedford Road.
Its route to St Georges Square will be closed, including parts of the A6 and the A505.
The main road closures are the A6 New Bedford road, from the Stockingstone road roundabout. Approach roads will be closed at their junction with the A6 along this stretch.
The A505 and its junctions will be closed northbound from the Telford Way roundabout.
Luton International Carnival is organised on behalf of the borough council by Luton Culture's Watch This Space events team.
Organisers say the parade will include up to 2,000 people and that the blend of Caribbean, African, Asian, English, Latin American and Irish music together with a variety of dance, food and entertainment will reflect the diversity of the town.
"One of the highlights of living in Luton is the Luton International Carnival", said council leader Hazel Simmons.
"This is a fantastic event showcasing what Luton has to offer - artistic flair and a wealth of talents and skills. With a reputation of being one of the safest carnivals in the country, it's a great day out for all the family," she said.
The BBC Introducing... team from BBC Three Counties Radio will be hosting the main stage in Wardown Park, showcasing the best in unsigned live music from across Bedfordshire, Hertfordshire and Buckinghamshire.
There will also be a special youth stage at Telford Way car park with sounds from locally-based DJs and MCs.