Drivers have been warned of disruption as the "key" part of a £7m upgrade starts to the Windsor and Eton relief road, ahead of the 2012 Olympics.
The carriageway is to be resurfaced as part of the revamp before the Games, where it will be a main route for the rowing events at Dorney Lake.
The work will take three weeks from mid-February with drivers warned to expect night-time closures.
Full details are available from Windsor and Maidenhead's council's website.
Councillor Colin Rayner, member for highways at the authority, said: "When tests were carried out before the works it was clear the road needed thorough resurfacing and repairs and we couldn't get away with a cosmetic makeover.
"We have tried to take every possible measure to reduce the impact on our residents and visitors, including ensuring the bulk of the work is carried out over the school half term.
"We apologise in advance to motorists for any inconvenience this work may cause."
The whole project is expected to be completed by April.