Three people with swine flu have died in East Yorkshire in the past fortnight, health officials have said.
Two women and a man, all aged under 50, have died in hospital in Hull during an outbreak in which 13 other cases have been confirmed.
One of the dead women had no other illness, but the other two victims had underlying health problems, Hull and East Yorkshire Hospitals Trust said.
Anyone who thinks they may have swine flu is urged to contact their GP.
Health bosses at Hull Royal Infirmary and the city's Castle Hill hospital said people should consult their doctor rather than immediately going to hospital.
NHS Hull also made fresh calls for people in "at risk" groups to have the flu injection.
Last week, the Health Protection Agency (HPA) weekly report said 24 people had died of swine flu in the UK this winter.
It has already been announced that the number of patients going to their doctor with flu-like illnesses has risen sharply in the past week.
But the HPA said a very large outbreak of swine flu was "not likely".
Last year nearly 500 people died with swine flu.