More than 100 NHS administration and managers' jobs in Leicestershire and Rutland are to be axed, health bosses have confirmed.
The counties' two primary care trusts plan to merge some of their management posts - with the loss of 106 posts.
NHS Leicestershire County and Rutland and Leicester City PCTs said the move follows a consultation on plans to reduce management costs by about 30%.
Health bosses said the £6m saving will be put into patient care.
Catherine Griffiths, chief executive of both NHS Leicester City and NHS Leicestershire County and Rutland, said: "Any redundancies are always regrettable but we need to reduce our management costs so that we can help the NHS budget stretch further.
"That is important as we face up to the inevitable financial challenges that lie ahead.
"It has been a difficult time for our staff but I have been really impressed with the resilience and commitment they have all shown."