Marks and Spencer stores in three Lincolnshire towns will close, the company has confirmed.
Branches in Grantham, Skegness and Scunthorpe will close early next year.
Campaigns to stop the closures were started in all three towns with the Skegness store collecting more than 20,000 signatures on a petition.
Marks and Spencer said it had seen years of falling sales which meant the three stores were no longer commercially viable.
Avril Smith, former manager of the Skegness store, said the company had made a bad decision.
"We are very disappointed indeed," said Ms Smith.
"I personally think they a making a grave mistake because this business won't go elsewhere."
About 110 posts will be affected when the stores close.
'Clear business strategy'
Doreen Stephenson, leader of East Lindsey District Council, said she was very disappointed to hear the news about the Skegness branch.
"It's a very sad day," she said.
"Obviously the council has made every effort it could within its responsibility and I have every sympathy with both the staff, residents and also our visitors who look forward to shopping in Marks and Spencer."
In a statement, a spokesperson from South Kesteven District Council said it was disappointing to learn the news about the Grantham store closure.
"Marks and Spencer have had a clear business strategy for some time to invest in their much larger retail sites. While this is disappointing, we must not forget our local, niche shops."
Marks and Spencer said that it had consulted with employees and had listened carefully to their views and suggestions.
It added it had also listened to the views of local residents but that none of the proposed alternatives it received would have made the stores commercially viable.