A 42-year-old woman who was suffering from swine flu has died in hospital in south Manchester.
The woman was admitted to Wythenshawe Hospital with severe flu symptoms and died on Thursday.
A University Hospital of South Manchester (UHSM) NHS Trust spokeswoman said it was not known if the patient had underlying health conditions.
Nationally, 27 people with flu have died so far this winter, the Health Protection Agency (HPA) has said.
The agency's weekly report, released on Thursday, said 24 had swine flu and nine of them were children.
The death of the woman, from Wythenshawe, is not thought to be included in the latest figures.
A post-mortem examination will be carried out to establish the cause of her death, the spokeswoman added.
The Health Protection Agency is continuing to urge pregnant women, the over 65s and people with health conditions to get the flu vaccination.
Figures released earlier this week showed the GP consultation rate for all flu had more than doubled in the past seven days to 87.1 per 100,000 in England and Wales.