The chief executive of NHS Telford and Wrekin is to leave as it tries to make savings of 40% by 2013.
Simon Connelly has worked for the health service in Shropshire for 18 years, the last eight of which he has been with the primary care trust (PCT).
His departure is part of the Mutually Agreed Resignation (MAR) scheme available nationally within the NHS, the PCT said.
The spokesman added his replacement was due to start on 1 November.
The scheme is a voluntary resignation scheme where staff apply to resign their contract of employment in return for a severance payment. It is not a redundancy scheme.
To make savings, the PCT is also looking at sharing resources with Shropshire, Herefordshire and Worcestershire, the spokesman said.