A new hotel, leisure facilities and offices could be built at a site just off junction 24 of the M5 in Somerset.
Submitted by Bridgwater Gateway Development, the plans also include a park and ride facility which could be used by EDF Energy.
The French-owned energy company has already consulted on a park and ride scheme there as part of plans for a new nuclear reactor at nearby Hinkley.
The plans are opposed by people living at nearby Stockmoor village.
They say the area would not be able to cope with the extra traffic and claim the value of some homes have decreased by £25,000.
Outline planning permission for the proposal has been granted by Conservative-run Sedgemoor District Council.
A council spokesperson said as the site was already part of its Core Strategy, developers would have to prove that there was not another site in Bridgwater which could encompass these plans.
EDF Energy wants to develop two new nuclear power stations in the UK by 2025 - one at Hinkley Point in Somerset, the other at Sizewell, Suffolk.
The site, which would serve the Hinkley Point nuclear power station, would also act as a freight storage area for the proposed Hinkley C development.
Bridgwater Gateway Development, which is a limited company set up by London-based investment company Miller Turner, has no commercial ties to EDF Energy.
The total area of the facility would be 11 hectares (27 acres).
The plans are to be discussed at a full council meeting at the end of the month.