Fifty homes in Sheffield were evacuated after police found dangerous chemicals believed to be linked to drug production.
South Yorkshire Police said a 100m cordon was put in place around Ridgehill Avenue, Intake, on Friday.
Residents were allowed to return home overnight after the bomb squad carried out a controlled explosion.
A 34-year-old man has been arrested for allegedly attempting to produce class A drugs, under the Explosives Act.
Police said a number of homes had to be evacuated after chemicals were found during a search of a property on Ridgehill Avenue on Thursday.
The 100m cordon was extended to 150m on Friday afternoon for the bomb squad to destroy all the chemicals in a controlled explosion.
The cordon was lifted at about 02:00 BST on Saturday.
South Yorkshire Police said: "Throughout this incident public safety has been of the upmost importance. [We] would like to thank local residents for their patience and apologise for any inconvenience caused."