Colm Donaghy has been appointed to the chief executive's job on the Belfast Health and Social Care Trust.
Mr Donaghy, who is currently the chief executive of the Northern trust, will replace William McKee who is retiring.
Leading the Belfast trust is one of the biggest jobs in the health service in NI. The trust has around 20,00 staff and an annual budget of £1bn.
Mr Donaghy has previously been chief executive of the Southern trust, a post he held for four years.
He joined the health service in 1992.
He is Director General of CAWT, a cross border organisation with representation from the health boards immediately north and south of the border.
He lead the taskforce that developed the suicide prevention strategy for Northern Ireland.