Manx2 is ending its service between Belfast and Cork just over a fortnight after one of its flights crashed killing six people.
The company said it had carried out a review following the crash on 10 February.
The service will continue to operate for another two weeks.
Six other people were injured when the Manx2 plane crashed on landing at Cork Airport in thick fog.
Manx2 said it would give full refunds to anyone booked to travel the route after 14 March.
Two of the six people who died were from Northern Ireland.
Brendan McAleese, who was originally from Tannaghmore, County Antrim, owned the Central Laundries business in Cookstown in County Tyrone, and was married with a young family.
The 39-year-old was a cousin of the Irish President Mary McAleese's husband Martin.
Pat Cullinan, 45, originally from Omagh, County Tyrone, was a partner in accountancy firm KPMG in Belfast.
The two crew on board the Manx2 flight from Belfast to Cork also died in the crash.
Jordi Gola Lopez, 31, was from Manresa, Barcelona.
The pilot of the Manx2 flight had been working with the airline for less than a year.
His British co-pilot, Andy Cantle, was from the north east of England.
The 27-year-old was previously a lifeboat volunteer in Sunderland.
Six passengers survived the air crash.
Among them; Donal Walsh from Waterford, Lawrence Wilson from Larne, County Antrim, Heather Elliott from Belfast and Brendan Mallon from Bangor.
A preliminary report from Irish air accident investigators is expected in early March.
Manx2 said it would give full refunds to anyone booked to travel on the route, on or after 14 March.
All other flights, including from Belfast to Blackpool, Isle of Man and Anglesey will continue as scheduled, the company said.