About seventy jobs are at risk at the Glasgow printing plant of publishers DC Thomson.
The family-owned firm said it had become increasingly less viable to retain the Glasgow facility due to declining print volumes.
It said the financial constraints the plant operated within had also become unsustainable.
DC Thomson produces a wide range of publications including The Sunday Post and The Beano comic.
The Dundee-based company plans to consult with staff on the proposed closure.
It is anticipated that, in the event of a closure, production will cease during 2012.
Last year the company closed a plant in Dundee, shedding 350 jobs.
Linda Holden, head of group HR, said: "The decision to enter into consultation with staff at our Port Dundas facility in Glasgow has been taken with great regret.
"It has been made on the basis that the plant has become unsustainable.
She added: "We intend to work with our staff to ensure the best possible outcome for each individual during this difficult period.
DC Thomson's Glasgow plant currently produces The Sunday Post and contract printing.
The company employs more than 2,000 people at three Dundee sites, and at offices in Glasgow, Manchester and London.
It produces more than 100 million copies of its newspapers, books, annuals, magazines and comics each year.