Edinburgh's BlindCraft factory is to close after more than 200 years because city councillors voted to shut it down.
The decision came amid emotional scenes at Edinburgh City Chambers following submissions from workers and other groups on their behalf.
Last week BlindCraft employees rejected a rescue package which would have seen them move to a three-day week.
Edinburgh City Council said it could no longer afford to spend £1m per year subsidising the loss-making factory.
A union spokesman said they would continue the fight to save the Craigmillar plant.
The organisation has been operating since 1793, when it was established as the Royal Blind Asylum, and makes beds and mattresses.
More than 60% of its employees are disabled.