Bangor's Farrar Road football ground is to be demolished and replaced by a supermarket.
Councillors in Gwynedd have granted planning permission for the development that will create 240 jobs.
It will allow the Welsh Premier League side to move to a new stadium with a site at Nantporth already earmarked.
Plans to redevelop Dickies boatyard in Bangor into housing and the old Post Office at Deiniol Road into a nightclub were also approved.
The football club has been looking to move from Farrar Road, its home since the 1920s, for the past 10 years.
At a planning meeting on Monday Deiniol Developments was granted permission for the supermarket along with associated road changes and landscaping.