The A547 had to shut after a lorry carrying fruit overturned in Conwy county,
The road was closed to traffic for most of Saturday between St Asaph Road and the A55 junction for Abergele.
The crash happened just before 01:00 GMT and diversions were lifted when the road reopened in the evening.
A man in his 30s was taken to Glan Clwyd hospital following the incident. His injuries are not believed to be serious, the ambulance service said.