The US government is not seeking a regime change in North Korea, the secretary of state says, amid tensions over Pyongyang's weapons programme.
"We're not your enemy," Rex Tillerson said, adding that the US wanted a dialogue at some point.
But a Republican senator said President Donald Trump had told him there would be a war with North Korea if its missile programme continued.
Pyongyang claimed its latest missile could hit the US west coast.
The second test of an intercontinental ballistic missile (ICBM) on Friday, celebrated by North Korean leader Kim Jong-un, was the latest to be conducted in defiance of a United Nations ban.
"We do not seek a regime change, we do not seek the collapse of the regime, we do not seek an accelerated reunification of the peninsula, we do not seek an excuse to send our military north of the 38th parallel," said Mr Tillerson, referring to the border between the Koreas.
"We're not your enemy, we're not your threat but you're presenting an unacceptable threat to us and we have to respond."
Analysis: No good options and little time
Barbara Plett Usher, US state department correspondent
North Korea's recent long-range missile tests have deepened concern about the threat Pyongyang poses to the US mainland, and strengthened determination here to prevent any strike. That's what the president had in mind in his war talk with Senator Lindsey Graham.
The Pentagon has updated military options, but at the same time says a confrontation would be catastrophic. In light of that, Mr Tillerson repeated at length that the US wasn't seeking regime change and said the goal was dialogue, but one not based on the assumption that North Korea could keep its nuclear weapons.
Pyongyang has categorically refused such terms.
The strategy, said Mr Tillerson, is a sustained campaign of peaceful but intensifying economic pressure to change its mind. But given the advances in ballistic technology demonstrated by the recent ICBM tests, there's growing doubt that denuclearisation is a realistic possibility.
As always, there are no good options when it comes to North Korea, but less time to pursue them.
President Trump has repeatedly criticised China, which shares a land border with North Korea and is its closest economic ally, for not doing enough to stop Pyongyang's weapons programme.
However, Mr Tillerson took a more diplomatic approach, saying that "only the North Koreans are to blame for this situation".
"But," he added, "we do believe China has a special and unique relationship, because of this significant economic activity, to influence the North Korean regime in ways that no one else can."
In a separate development, Republican Senator Lindsey Graham said that Mr Trump told him that there would be a military conflict between the two countries if Pyongyang continued with its aim to develop a missile programme with the US in its range.
"There will be a war with North Korea over their missile programme if they continue to try to hit America with an ICBM," Mr Graham said.
"He [Trump] has told me that, I believe him, and if I were China I would believe him too, and do something about it," he said in an interview with NBC's Today programme.
Mr Graham added: "If there's going to be a war... it will be over there. If thousands die, they're going to die over there. They're not going to die here. And he [Trump] has told me that to my face."
Despite the ongoing tests, most experts believe Pyongyang does not yet have the capability to miniaturise a nuclear warhead, fit it on to a long-range missile, and ensure it is protected until delivery to the target.
They say many of North Korea's missiles cannot accurately hit targets.
Others, however, believe that at the rate it is going, Pyongyang may overcome these challenges and develop a nuclear weapon within five to 10 years that could strike the US.