Miami Dolphins beat the Oakland Raiders 38-14 in their NFL regular season clash in front of a sell-out Wembley crowd.
Quarterback Ryan Tannehill hit form and pulled the strings as the Dolphins scored five touchdowns to secure their second win in four games.
The struggling Raiders failed to spark both offensively and defensively in London and remain winless this season.
Sunday's game was the first of three NFL matches scheduled to be played at Wembley in 2014.
|NFL at Wembley|
|2007: New York Giants 13-10 Miami Dolphins||2011: Chicago Bears 24-18 Tampa Bay Buccaneers|
|2008: San Diego Chargers 32-37 New Orleans Saints||2012: New England Patriots 45-7 St Louis Rams|
|2009: New England Patriots 35-7 Tampa Bay Buccaneers||2013: Pittsburgh Steelers 27-34 Minnesota Vikings|
|2010: Denver Broncos 16-24 San Francisco 49ers||2013: San Francisco 49ers 42-10 Jacksonville Jaguars|
The match was attended by 83,436 fans, and the two upcoming games are also sold out.
Black Eyed Peas frontman Will.i.am and legendary Dolphins quarterback Dan Marino were among the famous names in attendance.
The NFL are attempting to ramp up interest in the UK with the long-term aim of establishing an NFL franchise in London by 2021.
The Atlanta Falcons take on Detroit Lions at Wembley on October 26 before the Jacksonville Jaguars meet Dallas Cowboys on November 9.