Peyton Manning broke the NFL record for touchdown passes as he helped Denver Broncos thrash the San Francisco 49ers.
The 38-year-old quarterback eclipsed Brett Favre's previous record of 508 by throwing his 509th and 510th scoring passes during the 42-17 win.
Manning set his record in 246 games - of which 208 were with the Indianapolis Colts - while Favre reached his mark in 302 games.
"I'm very honoured and humbled to join a pretty unique club," said Manning.
|NFL's record touchdown passers|
|1. Peyton Manning||510|
|2. Brett Favre||508|
|3. Dan Marino||420|
|4. Drew Brees||374|
|5. Tom Brady||372|
"I was glad it was here in Denver. The fact we won the game certainly allows you to celebrate with your team.
"The touchdowns I've thrown have helped us win a lot of games. That's the only reason [the record is] somewhat special."
Manning, who missed the 2011 season with a neck injury that required surgery, joined the Denver Broncos in 2012.
"Well deserved Peyton," tweeted Favre. "Congratulations on breaking my record. Onto 600."