Captain Sam Warburton says the absence of wing George North will be a big blow for Wales against South Africa on Saturday.
However, North's replacement Liam Williams was described as a "fantastic player" by Warburton, who says the Scarlets player will relish the occasion.
Williams is one of three changes for Wales against the Springboks.
Warburton says Wales are "ready to go" for their final match of the autumn Test series in Cardiff.
Wales v South Africa, 14:30 GMT on Saturday, 29 November: Watch live on BBC Two, online, mobiles and BBC Sport app; live commentary on BBC Radio Wales, Radio Cymru & online; updates on BBC Radio 5 live; text commentary on BBC Sport website and mobiles. Highlights on Scrum V, BBC Two Wales from 19:00 GMT on Sunday, 23 November.