Paul McCloskey will take on Colombian Breidis Prescott in a WBA Light Welterweight title eliminator in Belfast on 10 September.
The Dungiven fighter will make his return to the ring at the Odyssey Arena after his controversial points defeat to Amir Khan in April.
Prescott, who is three years younger than McCloskey at 28, is the only fighter to have beaten Khan.
The undercard could see Carl Frampton facing Kiko Martinez.
Frampton's management say negotiations are at an advanced stage for former European champion Martinez to take on unbeaten Belfast prospect Frampton.
Martinez knocked out Bernard Dunne in the first round of a European title fight in August 2007 but then lost the EBU belt when outpointed by Rendall Munroe the following March.
The shock win over Khan in 2008 is one of Prescott's 19 knock-out victories.
The Miami-based Prescott stopped Khan inside a minute of the opening round.
"I promise that if Amir is watching, and he happended to forget what occurred back in 2008, I will give him a reminder by my performance on 10 September." said Prescott on Tuesday.
"I can only hope that after I win, Amir keeps his promise and gets back in the ring with me."
McCloskey lost out to WBA champion Khan in Manchester after a clash of heads in the sixth round.
It resulted in a cut above McCloskey's eye and after consultation with the ringside doctor the referee stopped the fight.
"The Amir Khan experience was obviously disappointing but what better way to come back from that than by beating the only man to have ever beaten him," said promoter Eddie Hearn.
"Paul is one win way from another crack at a world title and it's going to be a special night at the Odyssey."