Martin Rogan will take on Panama's Lewis Andreas Pineda for the vacant WBU heavyweight title at the Odyssey Arena in Belfast on 27 October.
The 40-year-old Belfast fighter will be contesting a belt previously held by heavyweight legend George Foreman.
A win for Rogan would make him Northern Ireland's first ever heavyweight champion of the world.
"I'm excited about bringing this fight to the city and I intend to win for the people of Belfast and beyond," he said.
Rogan added: "People always mention previous world title fights in the city and it would be nice if people could say they were at the Odyssey Arena in Belfast when we got our first world heavyweight champion.
"I will be the underdog but I love that and I'm going to do something very, very special on 27 October."
Rogan gets a tilt at a world crown after pulling out of a European Union title fight with unbeaten Bulgarian Kurbrat Pulev in Munich in July.
Rogan cited a lack of preparation time as the reason for his withdrawal.