Captain Marcus Trescothick will be rested for Somerset's three-day tour game against India, which starts on Friday at Taunton.
Trescothick was expected to play alongside England skipper Andrew Strauss, who is guesting for the side.
Director of cricket Brian Rose told the club website: "It is a long and taxing season for Marcus and the fixture list offers few chances to take a break.
"We want him to be fit physically and mentally for some big games ahead."
Somerset, who have qualified for the quarter-finals of the FL t20, currently sit fourth in the County Championship Division One table and are top of the CB40 standings.
Trescothick has been in impressive form this season, hitting six centuries across all competitions with a first class average of 74.93.